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Drug Development

Companion Diagnostics

CAM-captured iCTCs can be isolated to a high purity for discovery of drug-resistant targets in combination with NGS, PCR or gene expression profiling. 

Pure iCTCs are useful for molecular analyses of disease progression including gene mutations and expression levels indicative of pharmacodynamic response to cancer drugs, and novel targets for new drugs that act specifically and non-toxically on metastatic cells.

Training Set

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Testing Set

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Expression of epithelial/tumor (KRT, EpCAM, MUC16/CA125, CD24, Tert), progenitor cell/EMT/invasion (CD44v6, TWIST1, seprase) and endothelial (CD31, CDH5, VEGFR) genes of CTCs enriched by Vita-Cap™ from blood.