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  • Vita-Assay™Method of Enrichment and Identification of Circulating Cancer Cells/Circulating Tumor Cells (CTCs). 

    Published: 2016
    Participating Institutions: 
    Departments of Medicine and Gynecologic Oncology at Stony Brook Medicine, Stony Brook, NY.
    Authors: 
    Tulley,S., Zhao,Q., Dong,H., Pearl,M.L., and Chen,W.-T.

    Breast Cancer: Methods and Protocols, Methods in Molecular Biology, J. Cao, ed. (New York: Springer Science + Business Media), pp.107-119

  • An Improved CTC Isolation Scheme for Pairing with Downstream Genomics: Demonstrating Clinical Utility in Metastatic Prostate, Lung and Pancreatic Cancer

    Published: 2016
    Participating Institutions: Department of Urology, Division of Hematology & Oncology, Computational Biology Core, Genome Analysis Core, Department of Cellular and Molecular Pharmacology, Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco (UCSF), San Francisco, CA. 
    Authors: Premasekharan G, Gilbert E, Okimoto RA, Hamirani A, Lindquist KJ, Ngo VT, Roy R, Hough J, Edwards M, Paz R, Foye A, Sood R, Copren KA, Gubens M, Small EJ, Bivone TG, Collisson EA, Friedlander TW, Paris PL. 

    Cancer Lett: 380(1):144-52.doi10.1016/j.canlet.2016.06.017. Epub 2016 Jun 22

  • Breast Cancer Resistance Protein (ABCG2) as a Potential Biomarker for Gemcitabine and Nab-Paclitaxel Sensitivity. 

    Published: 2016
    Participating Institutions: 
    Memorial Sloan Kettering Cancer Center, New York, NY. Institute for Systems Biology, Seattle, WA; University of Maryland Greenebaum Cancer Center, Baltimore, MD.
    Authors: 
    Kenneth H. Yu, Mark Ricigliano, Eileen Mary O'Reilly, Maeve Aine Lowery, Brandon Cooper, Christina M. Covington.

    Journal of Clinical Oncology: 34, 2016 (suppl; abstr 4129).

  • Expression Levels of Aldehyde Dehydrogenase 1A1 (ALDH1A1) in Circulating Tumor and Invasive Cells (CTICs) as a Biomarker for Drug Resistance and Disulfiram in Pancreatic Adenocarcinoma (PDAC). 

    Published: 2016
    Participating Institutions: 
    Memorial Sloan Kettering Cancer Center, New York, NY. Institute for Systems Biology, Seattle, WA; University of Maryland Greenebaum Cancer Center, Baltimore, MD.
    Authors: 
    Mark Ricigliano, Brandon Cooper, Allyson J. Ocean, Herve Tiriac, David A. Tuveson, Kenneth H. Yu, Eileen Mary O'Reilly.

    Journal of Clinical Oncology: 34, 2016 (suppl; abstr e15755).

  • Treatment Monitoring of Patients with Epithelial Ovarian Cancer Using Invasive Circulating Tumor Cells (iCTCs).

    Published: 2015
    Participating Institutions: Departments of Medicine, Pathology and Gynecologic Oncology at Stony Brook Medicine, Stony Brook, NY; Department of Medicine and Research, Veterans Affairs Medical Center, Northport, NY.
    Authors: Pearl,M.L., Dong,H., Tulley,S., Zhao,Q., Golightly,M., Zucker,S., and Chen,W.T.

    Gynecological Oncology: 137, 229-238. doi: 10.1016/j.ygyno.2015.03.002. PMID:25769657

  • Gene-Pair Classifier in Circulating Tumor and Invasive Cells to Predict Pharmacological Response. 

    Published: 2015
    Participating Institutions: 
    Memorial Sloan Kettering Cancer Center, New York, NY. Institute for Systems Biology, Seattle, WA; University of Maryland Greenebaum Cancer Center, Baltimore, MD.
    Authors: 
    Vineet Sangar, John C Earls, Kenneth H. Yu.

    Journal of Clinical Oncology: 33, 2015 (suppl 3; abstr 279).

  • Prognostic Analysis of Invasive Circulating Tumor Cells (iCTCs) in Epithelial Ovarian Cancer.

    Published: 2014
    Participating Institutions: Departments of Medicine, Preventive Medicine, Applied Mathematics and Statistics, Pharmacology, Pathology and Gynecologic Oncology at Stony Brook Medicine, Stony Brook, NY; Department of Medicine and Research, Veterans Affairs Medical Center, Northport, NY.
    Authors: Pearl,M.L., Zhao,Q., Yang,J., Dong,H., Tulley,S., Zhang,Q., Golightly,M., Zucker,S., and Chen,W.-T.

    Gynecological Oncology: 134, 581-590.  PM:24972191

  • Transcription Regulation of Seprase in Melanoma Cells by Transforming Growth Factor-B Signaling.

    Published: April 13, 2014
    Participating Institutions: Departments of Medicine and Gynecologic Oncology at Stony Brook Medicine, Stony Brook, NY.
    Authors: Shaun Tulley and Wen-Tien Chen.

    Journal of Biological Chemistry: April 13, 2014 doi:10.1074/jbc.M114.568501.

  • Pharmocogenomic Modeling of Pancreatic Cancer (PDAC) for Prediction of Chemotherapy Response and Resistance in Second-Line Treatment Setting. 

    Published: 2014
    Participating Institutions: Memorial Sloan Kettering Cancer Center, New York, NY; START-Madrid, Centro Integral Oncológico Clara Campal, Madrid, Spain; Clinical Research Programme, Spanish National Cancer Research Centre-CNIO, Madrid, Spain; CellPath Therapeuthics, Inc, Baltimore, MD; Laboratorio de Dianas Terapeúticas, CIOCC, Madrid, Spain.
    Authors: Kenneth H. Yu, Vineet Sangar, Mark Ricigliano, Manuel Hidalgo, Eileen Mary O'Reilly, Ghassan K. Abou-Alfa, Maeve Aine Lowery, Joseph F. Crotty, Kristen Gary, Brandon Cooper, Rena G. Lapidus, Mariola Sadowska.

    Journal of Clinical Oncology: 2:5s, 2014 (suppl; abstr 4130).

  • Molecular and Genomic Characterization of Invasive Circulating Tumor Cells (iCTCs) from Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC). 

    Published: 2014
    Participating Institutions: Division of Genitourinary Medical Oncology and Department of Urology, Helen Diller Family Comprehensive Cancer Center, and Biostatistic and Computational Biology Core, University of California at San Francisco (UCSF), San Francisco, CA.
    Authors: Terence W. Friedlander, Gayatri Premasekharan, Vy Ngo, Shaun Doty, Anna Harris, Michael Winter, Elizabeth Gilbert, Charles Craik, Pamela Paris.

    Journal of Clinical Oncology: 32, 2014 (suppl 4; abstr 120).

  • Detection and Characterization of Invasive Circulating Tumor Cells Derived from Men with Metastatic Castration-Resistant Prostate Cancer

    Published: 2014
    Participating Institutions: Division of Genitourinary Medical Oncology and Department of Urology, Helen Diller Family Comprehensive Cancer Center, and Biostatistic and Computational Biology Core, University of California at San Francisco (UCSF), San Francisco, CA.
    Authors: Friedlander,T.W., Ngo,V.T., Dong,H., Premasekharan,G., Weinberg,V., Doty,S., Zhao,Q., Gilbert,E.G., Ryan,C.J., Chen,W.-T., and Paris,P.L.

    International Journal of Cancer: 134, 2284-2293. doi: 10.1002/ijc.28561. Epub 2014 Jan 2. PMID: 24166007.

  • The  End of the Beginning: Circulating Tumor Cells as a Biomarker in Castration Resistant Prostate Cancer

    Published: 2014
    Participating Institutions: Division of Genitourinary Medical Oncology and Department of Urology, Helen Diller Family Comprehensive Cancer Center, and Biostatistic and Computational Biology Core, University of California at San Francisco (UCSF), San Francisco, CA.
    Authors: Friedlander,T.W., and Fong,L.

    Journal of Clinical Oncology: 32:1104–1106.

  • Use of Pharmocogenomic Modeling in Pancreatic Cancer for Prediction of Chemotherapy Response and Resistance. 

    Published: 2013
    Participating Institutions: Memorial Sloan Kettering Cancer Center, New York, NY; START-Madrid, Centro Integral Oncológico Clara Campal, Madrid, Spain; Clinical Research Programme, Spanish National Cancer Research Centre-CNIO, Madrid, Spain; CellPath Therapeuthics, Inc, Baltimore, MD; Laboratorio de Dianas Terapeúticas, CIOCC, Madrid, Spain.
    Authors: Vineet Sangar, Mark Ricigliano, Eileen Mary O'Reilly, Ghassan K. Abou-Alfa, Maeve Aine Lowery, Leonard Saltz, Joseph F Crotty, Kristen Gary, Eun Yong Choi, Jing Yin, Manuel Hidalgo, Kenneth H. Yu.

    Journal of Clinical Oncology: 31, 2013 (suppl 4; abstr 142).

  • Looking Back, to the Future of Circulating Tumor Cells. 

    Published: 2013
    Participating Institutions: Division of Genitourinary Medical Oncology and Department of Urology, Helen Diller Family Comprehensive Cancer Center, and Biostatistic and Computational Biology Core, University of California at San Francisco (UCSF), San Francisco, CA.
    Authors: Friedlander TW, Premasekharan G, Paris PL.

    Pharmacol Ther.: 142(3):271-80. doi: 10.1016/j.pharmthera.2013.12.011. Epub 2013 Dec 19.

  • Feasibility to Obtain a Chemogram in Circulating Tumorigenic Cells to Further Treatments in Refractory Solid Tumors 

    Published: 2012
    Participating Institutions: START-Madrid, Centro Integral Oncológico Clara Campal, Madrid, Spain; Clinical Research Programme, Spanish National Cancer Research Centre-CNIO, Madrid, Spain; CellPath Therapeuthics, Inc, Baltimore, MD; Laboratorio de Dianas Terapeúticas, CIOCC, Madrid, Spain.
    Authors: Antonio Cubillo, Antonio Calles, Pedro P. López-Casas, Mark Ricigliano, Emiliano Calvo, Ignacio Duran, Fernando López-Ríos, Margarita Rodriguez, Manuel Hidalgo.
    Journal of Clinical Oncology: 30, 2012 (suppl; abstr 3066).
  • Plasma Seprase and DPP4 Levels as Markers of Disease and Prognosis in Cancer. 

    Published: 2012
    Participating Institutions: Departments of Medicine and Gynecologic Oncology at Stony Brook Medicine, Stony Brook, NY; Department of Medicine and Research, Veterans Affairs Medical Center, Northport, NY.
    Authors: Mazyar Javidroozi, Stanley Zucker, Wen-Tien Chen.
    Disease Markers: 35(5):309-20.
    PM:22674411
  • Isolation of circulating epithelial and tumor progenitor cells with an invasive phenotype from breast cancer patients.

    Published: 2010
    Participating Institutions: Departments of Medicine, Pharmacology, Pathology and Gynecologic Oncology at Stony Brook Medicine, Stony Brook, NY.
    Authors: PLu M, Fan T, Zhao Q, Zeng W, Zaslavsky E, Chen J, Frohman M, Golightly M, Madjewicz S, and Chen W-T.
    International Journal of Cancer 2010 Feb 1;126(3): 669-83
    PM:19662651; PMCID: PMC2795034 
  • Functional phenotyping and genotyping of viable circulating tumor cells from patients with hormone refractory prostate cancer.

    Published: 2009
    Participating Institutions: Division of Genitourinary Medical Oncology and Department of Urology, Helen Diller Family Comprehensive Cancer Center, and Biostatistic and Computational Biology Core, University of California at San Francisco (UCSF), San Francisco, CA.
    Authors: Pamela L. Paris, Yasuko Kobayashi, Qiang Zhao, Wei Zeng, Shivaranjani Sridharan, Wen-Tien Chen, Jonathan Rosenberg.
    Cancer Letter 277(2): 164-73
    PM:19162393
  • Clinical significance of circulating tumor cells detected by an invasion assay in peripheral blood of patients with ovarian cancer.

    Published: 2009
    Participating Institutions: Departments of Medicine, Preventive Medicine, and Gynecologic Oncology at Stony Brook Medicine, Stony Brook, NY; Department of Medicine and Research, Veterans Affairs Medical Center, Northport, NY.
    Authors: Tina M Fan, Qiang Zhao, John J Chen, Wen-Tien Chen, Michael L. Pearl.
    Gynecologic Oncology 112: 185-191
    PM:18954898; PMCID: PMC2606929 
  • Elevation of Seprase Expression and Promotion of an Invasive Phenotype by Collagenous Matrices in Ovarian Tumor Cells.

    Published: 2009
    Participating Institutions: Departments of Medicine,  and Gynecologic Oncology at Stony Brook Medicine, Stony Brook, NY.
    Authors: Kennedy, A. Dong, H., Chen, D., and Chen, W-T.
    International Journal of Cancer 124: 27-35
    PM:18823010; PMCID: PMC2597700 
  • Induction of Smad1 by MT1-MMP contributes to tumor growth.

    Published: April 23, 2007
    Participating Institutions: Departments of Medicine and Gynecologic Oncology at Stony Brook Medicine, Stony Brook, NY
    Authors: Freudenberg, Jaclyn Ann; Chen, W-T.
    International Journal of Cancer 121: 966-877
    PM:17455258; PMCID: PMC2084471 
  • Clinical Implications of Fibroblast Activation Protein in Patients with Colon Cancer.

    Published: 2007
    Participating Institutions: Departments of Surgical Oncology, Medical Oncology, Pathology, and Biostatistics, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
    Authors: Henry,L.R., Lee,H.O., Lee,J.S., Klein-Szanto,A., Watts,P., Ross,E.A., Chen,W-T., Cheng,J.D.
    Cancer Research 13: 1736-1741
    PM:17363526
  • Activation of EDTA-Resistant Gelatinases in Malignant Human Tumors.

    Published: 2006
    Participating Institutions: Departments of Medicine, Pathology and Gynecologic Oncology at Stony Brook Medicine, Stony Brook, NY; Department of Surgery, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Pathology, The National Hospital-The Norwegian Radium Hospital, University of Oslo, Oslo, Norway; Department of Gynecology and Obstetrics, Zhengzhou University, Henan, China; Department of Applied Medical Science, University of Southern Maine, Portland, Maine; Department of Pathology, Faculty of Medicine, Yamanashi Medical University, Shimokato Tamaho Nakakoma, Yamanashi, Japan; Department of Pathology, School of Medicine, Nihon University, Itabashi, Tokyo, Japan; and Dipartimento di Biologia Cellulare e dello Sviluppo, Università di Palermo, Palermo, Italy.

    Authors: D. Chen, A. Kennedy, J-Y. Wang, W. Zeng, Q. Zhao, M. Pearl, M. Zhang, Z. Suo, J. M. Nesland, Y. Qiao, A-K. Ng, N. Hirashima, T. Yamane, Y. Mori, M. Mitsumata, G. Ghersi, W-T. Chen.
    Cancer Research 66: 9977-85
    PM:17047060; PMCID: PMC1626657 

  • The Protease Complex Consisting Of Dipeptidyl Peptidase Iv And Seprase Plays A Role In The Migration And Invasion Of Human Endothelial Cells In Collagenous Matrices.

    Published: 2006
    Participating Institutions: Departments of Medicine and Gynecologic Oncology at Stony Brook Medicine, Stony Brook, NY; Department of Medicine and Research, Veterans Affairs Medical Center, Northport, NY.

    Authors: G. Ghersi, Q. Zhao, M. Salamone, Y. Yeh, S. Zucker, W-T. Chen.
    Cancer Research 66: 4652-61
    PM:16651416; PMCID: PMC1457118